MCC Analogs and their Reactivity with AND TCR


Here is a list of analogs of MCC88-103 with their relative antigenicity normalized to PCC 88-104 (PCC88-104 gives 40% of maximum proliferative response at 0.001- 0.03 uM depending on the day). For some reason or other we only know of one good antagonist which is the T102L analog. Another one is likely to be K99Q but it has to be PCC not MCC.

Unless noted, these are all MCC analogs
(Howard Grey, personal communication)

Position Substitution Relative antigenicity(PCC 88-104 = 1)
A96S1
G≤10-5
F10-2
N10-3
Y97V 10-2
I 10-3
F1
L98 N 1
E 10-1
K 1
K99 A 10-2
R 10-1
Q 10-3 (on PCC ≤10-5 -antagonist)
Q100 N 10-2
F 10-4
Y 10-3
A101 G 1
S 1
F ≤10-5
I 10-4
T102 S 1
V10-4
G1
I10-2
L ≤10-5 (good antagonist)


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