RECENT PUBLICATIONS

Pub Med

Utzschneider, D. T., A. Delpoux, D. Wieland, X. Huang, C. Y. Lai, M. Hofmann, R. Thimme, and S. M. Hedrick.(2018). Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep 22: 3454-3467. Full Article

Tsau, J.S., Huang, X., Lai, C.Y., Hedrick, S.M. (2018). The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.  J Immunol. 200(4): 1335-1346. Full Article

Delpoux, A., Michelini, R.H., Verma, S., Lai, CY, Omilusik, K.D., Utzschneider, D.T., Redwood, A.J., Goldrath, A.W., Benedict, C.A., Hedrick, S.M. (2018). Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.  J Exp Med. 215(2): 575-594.  Full Article

Morris, G. P., and Hedrick, S. M. (2017). A rheostat tuning thymic selection. Nat Immunol 18, 713-714.Full Article

Hedrick, S. M. (2017). Understanding Immunity through the Lens of Disease Ecology. Trends Immunol 38, 888-903.  Full Article

Delpoux, A., Lai, C. Y., Hedrick, S. M., and Doedens, A. L. (2017). FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity. Proc Natl Acad Sci U S A 114, E8865-E8874.  Full Article

Stienne, C., Michieletto, M.F., Benamar, M., Carrie, N., Bernard, I., Nguyen, X.H., Lilli, Y., Duguet, F., Liblau, R.S., Hedrick, S.M., Saoudi, A., Dejean, A.S. (2016). Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 18:45(4):774-787.  Full Article

Allison, K.A., Sajti, E., Collier, J.G., Gosselin, D., Troutman, T.D., Stone, E.L., Hedrick, S.M., Glass, C.K.  (2016). Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 5:e10134. Full Article

Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. (2016). Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs. Neuron. 90(3):535-50. Full Article

Mah I.K., Soloff R., Hedrick S.M., Mariani F.V. (2015). Atypical PKC-iota controls stem cell expansion via regulation of the notch pathway. Stem Cell Reports 5(5):866-880. Full Article

Kang, H., Corr, M., Mansson, R., Welinder, E., Hedrick, S.M., Stone, E.L.  (2015).  Loss of murine FOXO3 in cells of the myeloid lineageenhances myelopoiesis but protects from K/BxN-Serum transfer-induced arthritis.  PLoS One.  10(5): e0126728. Full Article

Stone, E.L., Pepper, M., Katayama, C.D., Kerdiles, Y.M., Lai, C.Y., Emslie, E., Lin, Y.C., Yang, E., Goldrath, A.W., Li, M.O., Cantrell, D.A., Hedrick, S.M.  (2015).  ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation.  Immunity. 42(2): 239-51.  Full Article

Lee, S.Y., Coffey, F., Fahl, S.P., Peri, S., Rhodes, M., Cai, K.Q., Carleton, M., Hedrick, S.M., Fehling, H.J., Zuñiga-Pflücker, J.C., Kappes, D.J., Wiest, D.L. (2014).  Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.  Immunity. 41(6): 934-46.  Full Article

Mingueneau, M., Krishnaswamy, S., Spitzer, M.H., Bendall, S.C., Stone, E.L., Hedrick, S.M., Pe’er, D., Mathis, D., Nolan, G.P., Benoist, C. (2014).  Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci USA.  111(46): 16466-71. Full Article

Cuda, C.M., Misharin, A.V., Gierut, A.K., Saber, R., Haines, G.K. 3rd, Hutcheson, J., Hedrick, S.M., Mohan, C., Budinger, G.S., Stehlik, C., Perlman, H. (2014).  Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation.  J Immunol. 192 (12): 5548-60.  Full Article

Roupé, K.M., Veerla, S., Olson, J., Stone, E.L., Sørensen, O.E., Hedrick, S.M., Nizet, V. (2014).  Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process.  PLoS One.  9(2): e89274. Full Article

Hess Michelini, R., Doedens, A.L., Goldrath, A.W., and Hedrick, S.M. (2013).  Differentiation of CD8 memory T cells depends on Foxo1.  J Exp Med. 210(6): 1189-200. Full Article

Ruff, L.E., Mahmoud, E.A., Sankaranarayanan, J., Morachis, J.M., Katayama, C.D., Corr, M., Hedrick, S.M., Almutairi, A.  (2012). Antigen-loaded oH-sensitivehydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies.  Integr Bio. 5(1): 195-203.  Full Article

Hedrick S. M., Michelini R.H., Doedens, A.L., Goldrath, A.W., Stone E.L. (2012). FOXO transcription factors throughout T cell biology. Nat Rev Immunol. 12:649-661. Full Article

Gu L, Ruff, LE, Qin Z, Corr M, Hedrick SM, Sailor MJ.  (2012).  Multivalent Porous Silicon Nanoparticles Enhance the Immune Activation Potency of Agonistic CD40 Antibody.  Adv Mater. 2012 Jun 12 Epub.  Full Article

Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick SM. (2012). Polar Opposites: Erk Direction of CD4 T Cell Subsets.  J Immunol. 2012 Jun 6 Epub.  Full Article

Hedrick SM. (2012) Positive selection in the thymus: an enigma wrapped in a mystery.  (2012).  J Immunol. 188(5): 2043-5. Full Article

Gunther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Walder MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C.  (2011).  Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis.  Nature 477(7364): 335-9.  Full Article

Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. (2011). Mechanisms of necroptosis in T cells. J Exp Med. 208(4): 633-41. Full Article

Kerdiles YM, Stone EL, Beisner DR, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM.  (2010). Immunity 33 (6): 890-904.  Full Article

Dejean AS, Hedrick SM, Kerdiles YM. (2011). Highly specialized role of Forkhead box O transcription factors in the immune system.  Antioxid Redox Signal. 14(4): 663-74.  Full Article

Hedrick SM, Ch'en IL, Alves BN. (2010). Intertwined pathways of programmed cell death in immunity.  Immunol Rev. 236: 41-53.  Full Article

Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A.  (2010).  Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.  J Immunol. 184(8): 4185-95.  Full Article

McGargill MA, Ch'en IL, Katayama CD, Pages G, Pouyssegur J, Hedrick SM. (2009).  Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.  J Immunol. 183(8): 4838-42. Full Article

Hedrick SM. (2009).  Immune system: not so superior.  Science 325(5948): 1623-4.  Full Article

Hedrick SM. (2009).  The cunning little vixen: Foxo and the cycle of life and death.  Nat Immunol. 10(10): 1057-63.  Full Article

Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.  (2009). MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.  Science 324(5929): 938-41.  Full Article

Dejean A S, Beisner DR, Kerdiles YM, Babour A, Arden K, Castrillon DH, DePinho RA., Hedrick SM. (2009) Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 10(5):457-8. Full Article

Kerdiles YM, Beisner DR., Tinoco R, Dejean, AS, Castrillon DH, DePinho RA, Hedrick SM. (2009) Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology. 10(2): 176-84. Epub 2009 Jan 11. Full Article

D'Souza WN, Chang CF, Fischer AM, Li M, and Hedrick SM. (2008). The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol 181, 7617-7629. Full Article

McGargill MA, Choy C, Wen BG, and Hedrick SM. (2008). Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol 181, 7593-7605. Full Article

Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, and Hedrick SM. (2008). Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A 105, 17463-17468. Full Article.

Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, and Wang T (2008). Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol 181, 2084-2091. Full Article

Ch'en IL, Hedrick SM, and Hoffmann A. (2008). NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol 446, 175-187. Full Article

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber, S. A., Lugovskoy, A., and Yuan, J. (2008). Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-321. Full Article

Hedrick SM. (2008). Thymus lineage commitment: a single switch. Immunity 28, 297-299. Perspective. Full Article

Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hubner A., Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, and Shokat KM. (2007). A semisynthetic epitope for kinase substrates. Nat Methods 4, 511-516. Full Article.

Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zornig M, and Lynch DH. (2007). The CD95 Receptor: Apoptosis Revisited. Cell 129, 447-450. Full Article

Hedrick SM. (2006). The TCR of mice and men. J Immunol 176, 2681-2682. Review-Perspective. Full Article

D'Souza WN, and Hedrick SM. (2006). Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol 177, 777-781. Full Article

Broussard C, Fleischacker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ and Schwartzberg PL. (2006). Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25, 93-104. Full Article

Fischer AM, Katayama CD, Pages G, Pouyssegur J, and Hedrick SM. (2005). The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23, 431-443. Full Article

Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, and Hedrick SM. (2005). Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8 J. Immunol. 175: Sept 15. Full Article

Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Pillars article[A.Weiss]: Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. [Nature, 1984, 308: 149-153] J Immunol. 2005 Sep 1;175(5):2771-5 Full Article

Goldrath AW, and Hedrick SM. Central Tolerance Matters. (2005) Immunity 23:113-114 Full Article

McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. Active Ca2+/Calmodulin-Dependent Protein Kinase II[gamma]B Impairs Positive Selection of T Cells by Modulating TCR Signaling (2005). J. Immunol. 175:656-664 Full Article

Catlett I, and Hedrick SM. Suppressor of Cytokine Signaling 1 is required for differentiation of CD4 T Cells (2005). Nat Immunology, 6:715-21 Full Article

Lin MY, Zal T, Ch’en IL, Gascoigne NRJ, and Hedrick SM. (2005). A Pivotal Role for the Multifunctional Calcium/Calmodulin-dependent Protein Kinase II in T Cells: from Activation to Unresponsiveness. J. Immunol. 174:5583-92 Full Article

Sato K, Imai Y, Higashi N, Kumamoto Y, Onami TM, Hedrick SM and Irimura T. (2005). Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood, 106:207-215 Full Article

Scott E C, ... [SM Hedrick] et al. 2004. The Morphology of Steve. Annals of Improbable Research, 10:24-29. Full Article

Hedrick SM. The acquired immune system: a view from beneath. (2004) Immunity, 21:607-615 Full Article

Soloff RS, Katayama C, Lin MY, Feramisco J and Hedrick SM. (2004) Targeted deletion of PKC lambda reveals a distribution of functions between the two atypical PKC isoforms. J. Immunol. 173:3250-3260. Full Article

McGargill M, Wen BG, Walsh CM, and Hedrick SM. (2004). A deficiency in Drak2 results in a T cell hypersensitivity, and an unexpected resistance to autoimmunity. Immunity, 21:781-791. Full Article

Brinkman-Van der Linden ECM, Angata T, Reynolds SA., Powell LD., Hedrick SM, and Varki A. (2003) Mouse CD33/Siglec-3: binding specificity, expression pattern and consequences of gene deletion in mice. Mol Cell Biol. 23:4199-206 Full Article

Beisner DR, Chu IH, Arechiga AF, Hedrick SM and Walsh CM.. (2003). The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 171:247-56. Full Article

Mertsching E, Wurster A, Katayama CD, Esko J, Ramsdell F, Marth JD, and Hedrick SM. (2002). A Mouse Strain Defective for ab vs. gd T Cell Lineage Commitment. Intl Immunol. 14(9):1039-53. Full Article

Hedrick SM. T cell lineage commitment: bottoms-up. (2002) Immunity, 16:619-622. Full Article

Tsujii M, Fujimori M, Oshashi Y, Higashi N, Onami TM, Hedrick SM, Irimura T. (2002). Molecular Cloning and Characterization of a Novel Mouse Macrophage C-Type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1. J Biol Chem. 277(32):28892-901. Full Article

Onami TM, Pag, DM, Bui J, Varki A, Varki N, and Hedrick SM. (2002) The generation of mice deficient for the macrophage galactose and N-acetylgalactosamine specific lectin: limited role in lymphoid and erythroid homeostasis, and evidence for multiple lectins. Mol. and Cell. Bio. 14:5173-81. Full Article

Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick SM, Murre C. (2001) Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2:165-71. Full Article

Hayden-Martinez K, Kane LP, and Hedrick SM. (2000). Effects of a constitutively active form of calcineurin on Tcell activation and thymic selection. J. Immunol., 165:3713-3712. Full Article

Jespen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick SM, Mandel G, Glass CK, Rose DW, and Rosenfeld MG. (2000). Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development. Cell 102:753-763. Full Article

Bui J, Calbo S, Hayden-Martinez K, Kane L, Gardner P, and Hedrick SM. (2000) A role for CAMKII in T cell memory. Cell 100:457-468. Full Article

Bain G, Quong MW, Soloff RS, Hedrick SM and Murre C. (1999) Thymocyte maturation is regulated by the activityy of the helix-loop-helix protein, E47. J Exp Med 190:1605-16. Full Article

Sharp LL, and Hedrick SM. (1999) Commitment to the CD4 lineage by Erk MAP kinase and Lck signaling. J. Immunol., 163:6598-6605.Full Article

Hedrick SM, and Sharp LL. (1998) T-cell fate. Immun. Rev., 165:95-110. NOT AVAILABLE IN PDF

Schwarz DA, Katayama CD, and Hedrick SM. (1998) Schlafen, a new family of growth regulators affect thymocyte development. Immunity, 9:657-668.Full Article

Jemmerson R, Minnerath JM, Hedrick SM, and Oehen S. (1998) B cell tolerance to a minor but not to a major antigenic surface of the self antigen cytochrome. J. Immunol., 161:2841-2847.Full Article

Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, and Hedrick SM. (1998) A role for FADD in T cell activation and development. Immunity, 8:439-449.Full Article

Page DM, Roberts EM, Peschon JD, and Hedrick SM. (1998) TNF receptor-deficient mice reveal startling differences between several modes of thymocyte negative selection. J. Immunol., 160:120-133.Full Article

Sharp LL, Schwarz DA, Bott CM, Marshall CJ, and Hedrick SM. (1997) The influence of the MAPK pathway on T cell lineage commitment. Immunity, 7:609-618.Full Article

Weintraub BC, Eckmann L, Okamoto S, Hense M, Hedrick SM, and Fierer J. (1997) Role of ab and gd T cells in the host response to Salmonella infection as demonstrated in T cell receptor deficient mice of defined ITY genotype. Infection & Immunity, 65:2306-2312.Full Article